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Its characterized by: excessive hair growth (hypertrichosis), papery thin and fragile (atrophic) skin, outward turned eyelids (ectropion) and a large mouth (macrostomia)

Evidence-based levers that reliably move the needle: A sustainable calorie deficit with adequate protein Resistance training plus daily movement Sleep and stress management (often underestimated) Clinician-guided options when appropriate, including FDA-approved obesity medications (e.g., Wegovy and Zepbound ) and weight loss injections A good rule of thumb: don't outsource a fundamentals problem to an unproven tool

Understanding how these medications work together matters because GLP-1 receptor agonists lower cardiovascular risk through multiple mechanismsweight loss, blood pressure reduction, and improved insulin sensitivity

The goals and opportunities for supporting brain health may also differ between midlife and older adulthood