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The peptide's effects were mediated through the downregulation of miR-339-5p expression, which was found to be part of the p38 MAPK pathway

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however, tracking the sequence of variations is very complex due to the fact that epigenetic alterations will modify both gene and promoter methylation, leading to epipolymorphism [41]

Unfortunately, to date, both predictive and diagnostic biomarkers have rarely been successful