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Additionally, the nitric oxide radical (NO ) is enzymatically synthesized from the oxidation of arginine to citrulline by nitric oxide synthase (NOS) (Hajam et al., 2022)

NAC should be continued until either liver function recovers or further intervention, such as liver transplantation, is warranted

Toxicol Appl Pharmacol 296:5460 Wise SS, Aboueissa AE, Martino J, Wise JP Sr (2018) Hexavalent chromium-induced chromosome instability drives permanent and heritable numerical and structural changes and a DNA repair-deficient phenotype

Its depletion under hyperglycemia exacerbates ROS accumulation, impairing insulin secretion