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Description
Here, we update and discuss current rationale, evidence, and dosing guidelines for mitochondrial medicine therapies in patients with PMD including practical considerations as to which therapies may be administered parenterally and which genetic etiologies and/or phenotypes might be particularly responsive to specific therapies[25]

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The risk of tolerance building, however, means the acute effects begin to diminish by weeks six to eight unless the user cycles off

Wright, 1987)
