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In addition to affecting these mostly mitogenic and survival pathways, merlin uncouples Ras/Rac growth factor receptor interactions 125 and has a negative feedback loop with PAK 80, 162, so that loss of merlin leads to Rac activation 94, which in turn leads to sustained and nonlocalized GTPase activation 61, 129
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doi: 10.17219/acem/63006
However, if you experience stomach distress when taking it on an empty stomach, you should consider taking it with a meal instead
