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The IRE1 pathway and its relationship with XBP1, RIDD, and JNK IRE1 is an ER-resident type I transmembrane protein with a luminal stress-sensing domain and dual cytosolic effector domains: one domain confers protein serine/threonine (S/T) kinase activity, while the other domain provides endoribonuclease (RNase) activity
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In both cell culture systems that we studied, microglial and dendritic cells, morphological alterations were connected with proinflammatory signaling [18,86]
