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The delay in Hgf and Cyclin D1 expression also coincided with differences in the kinetics of ERK1/2 phosphorylation between the two mice genotypes, suggesting that growth factor stimulation required for hepatocyte progression up to G1/S boundary was also altered

Clarifying this interplay is crucial, as CL not only binds -syn with high affinity but also determines whether it remains in a functional state or progresses toward toxic assemblies

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