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The human results were real but modest

Evidence also suggests that B12 deficiency can cause inflammation and damage to blood vessels, as well as oxidative stress, which combined can interrupt normal blood flow to the feet (Spence, 2016)

[6] [25] At levels only slightly below normal, deficiency can result in fatigue, headaches, feeling faint, rapid breathing, pale skin, numbness or tingling, poor appetite, heartburn, poor balance, difficulty walking, poor reflexes, blurred vision, memory problems, depression, irritability, inattention, cognitive decline, dementia, and even psychosis

B12 is naturally available only in animal proteins, so people who eat vegetarian or vegan diets may not consume enough B12