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The effects of plant products on health are primarily determined by the presence of secondary metabolites produced by the plant for protection against various external biotic and abiotic factors

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Additionally, M1 microglia are often associated with reduced phagocytic activity, which may also make microglia less effective at clearing Aos and plaques [98]

Over the past decade, advances in basic medical science have illuminated the structures and functions of key regulators of cholesterol metabolism, including the SCAP-SREBP complex [106], Insig- 1 [107], NPC1/2, ABCA1 [108], ABCG5, and ABCG8 [109]