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The study has shown that PLP can regulate glycocholic acid, taurocholic acid, glycodeoxycholic acid, L (D)-arginine, and L-tryptophan, and these metabolites are related to bile acid secretion and amino acid metabolism, which is concluded that bile acid metabolism may be involved in the therapeutic effects of PLP on cholestasis (Ma et al., 2016)

52102354, 52102180, 52202353, and 52372273), and the Science and Technology Development Planning Project of Jilin Province (Nos

33,78,104,114 Semaglutide Semaglutide is a long-acting GLP-1RA agent used once weekly to improve glycemic control in patients with T2DM