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Excessive ROS generation, including superoxide, peroxides, and free radicals, disrupts cellular function, promotes cell death, and contributes to neurodegenerative diseases such as Alzheimers disease, Parkinsons disease, and epilepsy ( At the mechanistic level, both 2HG enantiomers act as competitive inhibitors of -KG-dependent dioxygenases, but L -2HG is particularly potent
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Positive charge patterning and hydrophobicity of membrane-active antimicrobial peptides as determinants of activity, toxicity, and pharmacokinetic stability
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