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Rofleponide-C14 prodrug, predominantly distributed in the outer shell of LNPs, significantly reduced local and systemic inflammation when included in mRNA-LNPs encoding a model-secreted protein (hFGF21)

Our finding that CRP recruits and activates C1 on the surface of MSU crystals suggests that CRP binds MSU crystals via its binding face, which leads to a conformational change that enables C1 binding to the effector face of CRP