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Both the mRNA and protein levels of PSAT1 in ER-positive primary tumors are associated with poor clinical outcomes following tamoxifen treatment, suggesting that combination with a regimen targeting PSAT1 might enable therapeutic efficacy in this subset of breast cancer 26

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Therefore, to achieve successful phytoremediation of soils through the production of Hg hyperaccumulators, it is important to understand the mechanisms of Hg accumulation and tolerance in plants, for example, the regulation of Hg uptake and exclusion, chelation, vacuolar compartmentalization, and reactive oxygen species (ROS) homeostasis (Natasha et al., 2020)

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