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Based on pharmacokinetics, most drugs are cleared from the liver after entering the body, and only the remaining fraction reaches the target organ to exert therapeutic effects

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In contrast, supervised analysis of biopsy CyTOF data demonstrated a borderline significant increase in HLA-DR + IECs in UC and UC-VDZ samples compared to HC, and a trend toward reduced CD15 hi IECs in UC, with expansion in VDZ-treated patients (Fig

2.5.2 cDNA synthesis and RT-qPCR Reverse transcription was conducted with 40 ng of RNA per sample using the Reverse Transcription Master Mix Kit (Fluidigm Corporation, San Francisco, California, USA), following the manufacturers instructions