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Systemic circulation is generally characterized by an oxidizing milieu, whereas intracellular compartments exhibit substantially more reducing conditions, creating opportunities for selective and site-specific cargo release

For instance, lentiviral vectors engineered viruses used to stably deliver genes into target cells for gene therapy have been used to target the dynein axonemal intermediate chain 1 gene in airway epithelial cells, restoring ciliary beating for primary ciliary dyskinesia treatment

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Simonovic M, Puppala AK