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Free Radical Biol Med 20(5):675705

The mechanisms that implicate the declining of age-related ascorbate are complex and involve multiple cell signaling pathways such as accelerated turnover, increased usage, reduced cellular uptake, and decreased absorption/reabsorption

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There are a few mechanisms of LINE1 hypomethylation studied: [1] LINE1 hypomethylation increases the oxidative stress in bladder cancer, thereby promoting tumor progression [139] and [2] hypomethylation of the LINE1 promoter can induce an alternate splice variant of MET oncogene in bladder tumors, leading to tumor progression [140, 141]