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Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death

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Interestingly, in vitro studies show that intestinal epithelial cells express RGD-dependent integrins, which recognize the RGD motif found in many ECM molecules, such as fibronectin, to anchor to the ECM and control their position and fate

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