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This suggests the fluctuation in succinate, itaconate and 2-HG, could influence the dynamic changes in HIF-1 upon both continual and acute stimulation

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Pitfalls in the analysis of the physiological antioxidant glutathione (GSH) and its disulfide (GSSG) in biological samples: an elephant in the room
Regarding inflammatory mediators, berberine significantly reduces the levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF- ), interleukin-6 (IL-6), and IL-1 , and downregulates their protein expression [210]
