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Orlistat (Alli, Xenical) works by blocking fat absorption and predictably causes fatty, loose stoolsmaking it unsuitable for patients seeking to avoid diarrhea
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As pointed out earlier in this review, transgenic animal studies disrupting one or more IGFBPs have not suggested that a marked growth phenotype should be expected in children and no IGFBP mutations causing growth retardation in children had been reported to the best of my knowledge
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