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Description
Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial
& Fry, S
BMC Genomics, 12 , 112
Borosilicate glass pipettes (2.55 m) filled with 125 mm K + -gluconic acid, 10 mm NaCl, 4.6 mm MgCl, 4 mm K2-ATP, 15 mm creatine phosphate, 10 U/ml phosphocreatine kinase, and 1 mm EGTA (pH 7.3, 300 mOsmol)
