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Nasal testosterone has a short duration of action and appears to have the advantage of preserving fertility in men of reproductive age with low testosterone levels

MK-677 stimulates Growth Hormone and IGF-1 which each factor in significantly to maintaining lean body mass

its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin