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The long non-coding RNA MALAT1 activates the NRF2 transcription factor, enhancing the expression of antioxidant genes such as HO1, NQO1, and GCLC, which helps protect cells from oxidative stress-induced damage [167]

Since Zip14 KO did not completely inhibit efflux, other transporters, such as ZIP8, may also contribute, though in vivo studies are needed to confirm this

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Combining glutathione with nutrients such as vitamin C or other antioxidants is a common approach in aesthetic treatments, aiming to enhance overall effectiveness through synergistic action
