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Genes encoding enzymes in the gluconeogenesis pathway that are subject to regulation by ChREBP such as G6PC1, which encodes the predominant form of glucose-6-phosphatase, and FBP1 which encodes the liver form of fructose-1,6-bisphosphatase

Consistent with previous studies (57), daf-2 mutants exhibited a significant increase in fat storage (Fig 3C and D)

Ca 2+ efflux is mediated by Ca 2+ -ATPase pumps and Ca 2+ /cation antiporters, which restore basal [Ca 2+ ] cyt levels ( 2+ -ATPases (ACAs), belonging to the P-type Ca 2+ -ATPase family, export cytosolic Ca 2+ using ATP hydrolysis ( 2+ /cation antiporter (CaCA) superfamily also plays a crucial role in cation homeostasis and stress responses

Because of these changes in valproate clearance, monitoring of valproate and concomitant drug concentrations should be increased whenever enzyme inducing drugs are introduced or withdrawn