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This is also evident in other models such as the chronic social defeat stress model of depression which is associated with a decrease in claudin-5 expression in the nucleus accumbens while viral-mediated downregulation of claudin-5 is sufficient to induce depressive-like behaviours 33

A small dressing is applied to the injection site after the needle is removed

This receptor interaction also underlies its lipid-modifying effectsinhibiting lipolysis in adipose tissue , which reduces free fatty acid flux to the liver and lowers VLDL/triglyceride production

A systematic review of clinical studies in humans has shown that St
