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Since 2024, there has been a large effort to biochemically and structurally characterize human FLVCR proteins, leading to 13 different deposited structures of FLVCR1 and FLVCR2, several with either choline or ethanolamine bound in a central binding pocket (18, 33, 35)

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Accordingly, our structural and biochemical data do not support a regulatory switch mechanism for the MSA-DH enzyme from A

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