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In fact, EDCs may not have the ability to modify DNA sequence but can alter the DNA methylation patterns, induce histone modification and miRNA regulation leading to transcriptional changes associated with different diseases such as hormone production disruption (Figure 3), affecting neuroendocrine system dysfunction (142), prostate carcinogenesis process (95), change in behavior responses (73), and tumor formation in second generation (F2) mice (143, 144)

[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Bhinge S.D., Bhutkar M.A., Randive D.S., Wadkar G.H., Todkar S.S., Savali A.S., Chittapurkar H.R

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Ibutamoren (MK-677) Ibutamoren is a growth hormone secretagogue (GHS) that mimics ghrelin, a hunger-related hormone, to stimulate a sustained release of GH and Insulin-like growth factor 1 (IGF-1)