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As pointed out by Kim et al

On the one hand, excessive ROS generation is involved in the process of chondrocyte growth inhibition and apoptosis promotion through signaling pathways, such as PI3K/AKT and p38 pathways (238, 239)

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Peptidergic Pain Reducing Effects Of The Delta-Sleep-Inducing Peptide (Dsip) In Headache And Other Pain Syndroms