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2017;12:e0186374

Maier-Hauff K, Rothe R, Scholz R, et al

Short-term effects (first 12 weeks) Injection-site irritation : redness, itching, or swelling Headaches or nausea : usually mild and temporary Fatigue or drowsiness : some people feel extra tired at the start Water retention or bloating : often resolves as your body adjusts Occasional but less common effects Joint stiffness or aches Tingling or numbness (paresthesia, often in the hands or feet) Increased appetite These usually fade as your body adapts, but if they linger, its worth checking in with your provider

Neuromelanin, an oxidation-derived pigment from DA, has been reported to fuel inflammation in certain conditions such as in PD through microglia activation