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Treating sexual dysfunctions

Researchers wanting to replicate established protocols precisely should use the same delivery method

8-week on, 4-week off example: Weeks 1-2: Assessment and dose finding (every other day) Weeks 3-6: Optimization phase (3-5 times weekly) Weeks 7-8: Maintenance (3 times weekly) Weeks 9-12: Complete break, no DSIP During the off period, focus on sleep hygiene fundamentals: consistent wake times, light exposure management, temperature optimization, and stress reduction

There was a positive trend in the Composite SLE Responder Index in the Intention-to-treat (ITT) cohort, and post-hoc analysis showed that the BILAG secondary endpoint was met for a number of subgroups dosing levels, including low or no steroids, seropositivity, and patients with 2 grade BILAG improvement