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The predictors of pemetrexed toxicities were poor Eastern Cooperative Oncology Group performance status (ECOG-PS) and low body mass index (BMI) for febrile neutropenia (FN), concomitant chronic infectious disease, bevacizumab use for neutropenia, poor ECOG-PS for thrombocytopenia, and low serum albumin levels for non-hematologic toxicities

Many of these agents, including peptide-based and hydrophobic small molecules, exhibit poor CNS bioavailability, necessitating advanced delivery systems such as nanoparticles, convection-enhanced delivery, or BBB permeabilizing strategies [113, 153]

Arthritis is an umbrella term for over 100 different types of joint inflammation that can cause pain, swelling, stiffness, and reduced joint mobility

Until that process concludes, compounding access remains in a regulatory transition period