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Gene-level modulation: Pickart & Margolina 2018 documented activity across ~4,000 human genes, with fibroblast expression patterns shifting closer to younger cells

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A randomised controlled trial published in Clinical Infectious Diseases demonstrated that Thymosin Alpha-1 treatment in severe COVID-19 patients reduced 28-day mortality by 30% compared to standard care alone.17 While this was acute disease, not long COVID, it confirms the biological plausibility of the immune mechanism