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Efforts to improve study cohorts have included the adoption of standardized criteria such as the Canadian Consensus Criteria (CCC) and the CDC-1994 criteria (Carruthers et al., 2023)

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Likewise, an increased expression of antioxidant proteins, such as heme oxygenase (HO-1), known to limit inflammatory response, or NQO-1, glutathione reductase, glutathione peroxidase 2, and GST-pi, was also reported [51]