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doi: 10.1093/rheumatology/keae074

2.3 Synaptic dysfunction and abnormal neural plasticity A core feature of neurodegenerative diseases is synaptic loss and dysfunction, a principle that finds a compelling parallel in the pathophysiology of tinnitus
Many ALS/FTD causative genes exert toxicity by disruption of key pathways such as nucleocytoplasmic transport and cellular stress responses [22]

Endocrinology 137 , 24902502 (1996)
