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Cobalamin deficiencies in adults: update of etiologies, clinical manifestations and treatment

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Phytomedicine 2014, 4 (1), 114

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When it takes place at gene promoters, DNA methylation results in transcriptional repression either via interfering with the binding of transcription activating factors or by recruiting transcriptional repressors such as methyl-binding proteins, histone deacetylases (HDACs), and histone methyltransferases that reduces chromatin accessibility [17]

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Am J Physiol 1998

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