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The effectiveness of cosmetic peptides can vary significantly due to several factors
[DOI] [PubMed] [Google Scholar] Ueda K, Shimabuku AM, Konishi H, Fujii Y, Takebe S, Nishi K, Yoshida M, Beppu T, Komano T
These hormones remain in the colloid center of the thyroid follicles until TSH stimulates endocytosis of colloid back into the follicle cells

All these peptide hemichannel inhibitors, however, cannot cross the bloodbrain barrier, which limits their clinical potential