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Melatonin has been reported to bind KEAP1, thereby disrupting this interaction and permitting NRF2 to translocate to the nucleus where it can activate antioxidant response element (ARE)-driven gene expression (25, 41, 62, 63)

This opens the way for the development of other rational, hypothesis-based therapies

A major antioxidant involved in reducing oxidative stress, enhancing metabolic detoxification, and regulating the immune system, glutathione levels were found to have skyrocketed in metastatic cancer cells that invaded the lung

This makes it particularly dangerous for individuals with pre-existing heart conditions