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In rats, dietary zinc deficiency increased lead and cadmium accumulations in various organs, resulting in impaired skeletal growth, increased neoplastic progression of testicular lesions and enhanced chronic progressive nephropathy (Bushnell and Levin, 1983

Iron-responsive element-binding protein 2 (IREB2) is a regulator of iron metabolism, which can up-regulate the expression of ferritin light chain and ferritin heavy chain in the cytoplasm during iron metabolism, and alleviate erastin-induced ferroptosis (Mishima, 2022)

As recommended by European Renal Best Practice guidelines, the maintenance of an optimal intravascular volume using isotonic crystalloids rather than colloids and, when possible, the exclusion of any potential nephrotoxic drugs may reduce the risk of worsening renal function in the early period after kidney transplantation