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Markedly, induction of cardiolipin and acyl-carnitine levels as well as oxidation of oleic acid upon starvation are completely absent in hlh-30 animals, arguing that HLH-30 is required for induction of mitochondrial -oxidation during starvation

Majid Alfadhel, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia Updates Copyright 2019 Dhir, Tarasenko, Napoli and Giulivi

POLG-related disorders should be suspected in patients with a family history or suggestive symptoms of a POLG-related disorder, including but not limited to unexplained encephalopathy, refractory epilepsy (focal, myoclonic), status epilepticus at presentation, developmental delays, psychomotor regression, axonal sensorimotor neuropathy, myopathy cerebellar ataxia, ophthalmoplegia, or complicated migraine with occipital aura

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