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Any impurities or contaminants can directly interfere with the delicate signaling pathways it's being researched to influence

Psychosomatics 45:8487 OHearn E, Battaglia G, De Souza EB, Kuhar MJ, Molliver ME (1988) Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity

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