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Patients with severe MTHFR deficiency (0-20% residual enzyme activity) in infancy or adolescence present with developmental delay, severe mental retardation, motor and gait dysfunction, seizures, psychiatric disturbances, and other neurological abnormalities

A small but significant portion undergoes cytochrome P450 (CYP2E1) oxidation, producing the reactive intermediate N-acetyl-p-benzoquinone imine (NAPQI)

To locate the site, lie on your back while your partner stands facing your hips

Choline and inositol play physiological roles in lipid transport, but administering supraphysiological doses via injection has not been proven superior to dietary intake or oral supplementation