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The structural S protein is approximately 180200 kDa in size and is made up of an extracellular N-terminal domain, receptor-binding domain (RBD) in the S1 subunit, an intracellularly located C-terminal domain, transmembrane (TM) domain, and heptad repeat 1 (HR1) and HR2 located in the S2 subunit [20]

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study in Gastroenterology remains the foundational paper supporting KPV as one of the leading peptides for gut health via its oral delivery mechanism, demonstrating PepT1-mediated transport in Caco-2 cell models and murine colitis models with measurable reductions in colonic inflammation