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The prevalence of kidney stones is 10.6% in men and 7.1% in women, with a high recurrence rate50% within 5 years and up to 80% within 10 years [3]
Fluctuations in SHBG concentrationsmodulated by metabolic status, insulin levels, and hepatic functioncan therefore influence the proportion of free E2 available for receptor activation, adding an additional regulatory layer to phase-dependent hormonal effects [28,29]
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