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At present, systemic administration has been used to deliver antibodies, antibiotics, and carbonic anhydrase inhibitors to treat diseases such as endophthalmitis, elevated intraocular pressure, and uveitis [123126]

A growing body of translational research suggests that IN delivery can achieve CNS therapeutic effects while minimizing systemic exposure, allowing patients to experience fewer adverse effects, such as anemia or gastrointestinal upset, which are common concerns with oral or intravenous chelators

Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53

10.3390/agronomy15040867 49 JoshiS.De BrittoS.JogaiahS.ItoS