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PCLS reflects the complex cellular composition and the matrix effects of a diseased human lung, and biological diversity underlying differential treatment response in patients may well be studied in PCLS from different patients ( Figure 2 )

Examining Nutrition Strategies to Influence DNA Methylation and Epigenetic Clocks: A Systematic Review of Clinical Trials

Wu Y, Sun X, Song B, Qiu X, Zhao J

Abstract The hypoxic microenvironment, characterized by significantly reduced oxygen levels within tissues, has emerged as a critical factor in the pathogenesis and progression of various autoimmune diseases (AIDs)
