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If glutathione stores are exhausted, however, the reactive intermediate combines with sulfhydryl groups on essential hepatic cell proteins, resulting in cell death
In addition to somatic mutations in Keap1 , hot-spot mutations in the NFE2L2 gene in regions encoding the ETGE and DLG motifs in Nrf2 that bind to Keap1 have also been reported [383, 406410]
Juenemann et al., 2020
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