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In the case of suspected cobalt hypersensitivity, an intradermal test dose should be administered because anaphylactic shock and death have followed parenteral administration of methylcobalamin

Nano-carriers with surface-modified neutral or weak anionic groups (such as nanoparticles coated with hyaluronic acid) can reduce non-specific binding to blood components and enter the brain parenchyma through adsorption-mediated endocytosis

A study of peptide extract derived from natural source which is Lates calcarifer (LCEP) possesses the angiogenesis promoting property

However, taking into consideration that Vit B12 deficiency can induce the elevation of Hcy levels, it seems plausible to consider the non-motor aspects related to Hcy (Shipton and Thachil 2015)
