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In (A) and (B) m/z 1183.9 corresponds to insulin-SF MH55+ and in (A) m/z 235.0 corresponds to Gly-SF, the N-terminal amino acid of insulin A chain and in (B) m/z 325.2 corresponds to Phe-SF, the N-terminal amino acid of insulin B chain

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Multiple preclinical studies have demonstrated that co-targeting glycolysis and mitochondrial metabolism, or modulating key metabolic regulators such as AMPK, can significantly enhance the sensitivity of CRC cells to chemotherapy and targeted agents