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Introduction 5-Amino-1-methylquinolinium (5-Amino-1MQ) is an emerging compound of interest in metabolic and aging-related research due to its role as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT)

It is not a toxicity concern but an efficacy consideration

Even the small folate cycle can only proceed to a limited extent because the supply of THF from the large folate cycle is no longer given