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However, one iron chelator (deferoxamine mesylate) and one antioxidant agent (vitamin E) were capable of inhibiting cell death triggered by RSL, indicating the effects of iron as well as reactive oxygen species (ROS) ( RAS mutations by Mechanism of ferroptosis Ferroptosis has a distinctive morphological alteration compared with other PCDs such as apoptosis, necrosis, pyroptosis, and autophagy