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Role of garlic in the prevention of ischemiareperfusion injury

Tanshinone IIA also suppresses mitochondrial dysfunction by modulating the MAPK pathways in the neuroblastoma cell line (Li et al., 2017)

3.3.2 Reciprocal crosstalk among macrophages, fibroblasts, and tumor cells The progression of fibrosis to cancer is stimulated by a closely interconnected and self-reinforcing trilateral feedback loop involving macrophages, fibroblasts, and epithelial/cancer cells, leading to a continuous potentiation of pro-tumor signals (200202)

By employing a conditional gene expression strategy on an ApoE knockout background to eliminate interference from endogenous central ApoE, the study demonstrated that peripheral expression of ApoE4 alone is sufficient to induce memory impairment, BBB leakage, and perivascular gliosis, with a severity comparable to that observed in systemic ApoE4 expression models [88]